Medical Cannabis in Maryland Presentation (Excerpts)

Deborah Miran, Commissioner

Maryland Medical Cannabis Commission

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Medical Cannabis Milestones of the Twentieth Century

1940- Cannabidiol (CBD) was identified as a constituent of the plant

1964- Tetrahydrocannabinol (THC) identified and synthesized in Israel 

1988-1993- Two cannabinoid receptors discovered-proof of endocannabinoid system in body

1992-1995- Two endocannabinoids discovered


Function of the Endocannabinoid System

•Regulation of functions which control eating, sleeping, relaxation, memory and movement

•Endocannabinoid system is basic to all other systems in the body

•Evidence that the endocannabinoid system begins to form within days after fertilization.


•Overview of Endocannabinoid System

Cannabinoid receptors – Type 1

  -These are  the most extensive receptors

  -Found in the brain, spinal cord, peripheral nervous system, organs, and tissues.

•Cannabinoid receptors – Type 2

       -Found in immune system